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Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)
Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ...
An evaluation of the microbiological quality of commonly marketed dietary supplements in retail pharmacies in Kampala City, Uganda
(Makerere University, 2023)
Background: Dietary supplements are products that contain concentrated sources of nutrients and whose purpose is to add nutritional value (supplement) to normal diet. One of the critical indicators of the safety of dietary ...
B cell responses, immune modulation, and survival among patients with HIV-associated cryptococcal meningitis.
(Makerere University, 2023-01-17)
ABSTRACT
Introduction: A clear mechanism to advance treatment that would improve survival after HIV-associated cryptococcal meningitis despite antifungal therapy in sub-Saharan Africa remains elusive. We hypothesized ...
Comparative assessment of regulatory T and B cell phenotype frequencies in active, latent and Tuberculosis negative individuals
(Makerere University, 2023-01-01)
Background: Literature shows that regulatory B cells (Bregs) and regulatory T cells (Tregs) play a part in the control of many inflammatory diseases including tuberculosis (TB) by regulating the CD4 Tcell responses. This ...
Performance evaluation of computational programs to predict Human leucocyte antigen (HLA) genotypes on African whole exome sequence data
(Makerere University, 2023)
Introduction: Accurate Human Leucocyte Antigen (HLA) genotyping is critical in studies involving the immune system and transplantation medicine. HLA genes encode proteins that have a central role in immune responses that ...
Immunological and genetic risk factors associated with cognitive and neurological impairment in severe malaria in Ugandan children
(Makerere University, 2023)
Background. Endothelial activation is involved in pathophysiology of severe malaria leading to blood-brain-barrier dysfunction (BBB), which could occur in the absence of neurologic signs, or may be associated with long-term ...
Inflammaging and anti-inflammaging cytokines in the HIV-seropositive geriatric population in Uganda
(Makerere University, 2023)
Background: Although the life expectancy of people living with HIV (PLWH) has increased significantly, HIV infection seems to be associated with accelerated ageing processes compared to uninfected individuals. Longevity ...
Prevalence of protective levels of anti-HBs antibodies among 15-17 year old adolescents at kawempe division,Kampala,Uganda
(Makerere University, 2023-11-04)
BACKGROUND: Viral hepatitis is a global pandemic and HBV is one of the leading causes of liver-related cancer and cirrhosis. The inclusion of the HBV vaccine in National Immunization programs has contributed to the reduction ...
Characterisation of Candida africana among pregnant women with vaginitis
(Makerere University, 2023-11)
Candida africana, an emerging variant within the Candida albicans complex, has a global intra-albicans complex prevalence of 1.67% and varies between 0% and 8.4% depending on the region. It mainly causes vulvovaginal ...
Moral distress and coping strategies among nurses and midwives at Kawempe National Referral Hospital Kampala District
(Makerere University, 2023-07-28)
Background: Moral distress is a major issue in nursing practice, especially for those in clinical care. The existence of such distress may affect nurses’ physical and mental health, as well as their quality of life and ...