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Utility of urine LAM Biomarker for treatment response monitoring during 8 weeks of MDR-TB treatment at Mulago National Referral Hospital
(Makerere University, 2022-03)
Background: The current methods used in monitoring treatment response among MDR - TB patients have low sensitivity, take long to give results, are expensive and require BSL3 facilities. It is known that MTB LAM as a biomarker ...
Knowledge, attitudes and practice of ethics among plant agricultural researchers at the National Agricultural Research Laboratories, Kawanda-Uganda
(Makerere University, 2022-04-25)
Background: Plant agricultural research plays an important role and contributes significantly to human health and livelihood. With the current advancements in technology, this research is not exempt from ethical issues and ...
Characterizing the composition of the airway microbiota of patients with COPD in a rural setting in Uganda using shotgun metagenomics, a case control study
(Makerere university, 2022-10-25)
Introduction:
Diverse airway microbiota play an important role in the development and integrity of the immune system that limits growth of pathogenic microorganisms and clearing bacterial infections. Community shifts from ...
Comparative genomics of Staphylococcus aureus isolates from Africa using virulence and drug resistance markers
(Makerere University, 2022-08)
Introduction
There is wide diversity among Staphylococcus aureus lineages colonizing and infecting the African population, yet information on S. aureus infections in Africa is limited. Africa bears a particularly high ...
Genetic Diversity of Bundibugyo ebolavirus from Uganda and the Democratic Republic of Congo
(Makerere University, 2022-01-02)
Background
The Ebola virus is one of the deadliest known viral pathogens. It was first discovered in 1976 during two consecutive outbreaks in the Democratic Republic of Congo (DRC) and Sudan. Since then six known strains ...
Low-abundance drug resistant variant patterns among HIV-1 patients with virological failure in Uganda
(Makerere University, 2022-03)
Background: The emergence and spread of antiretroviral drug resistant HIV-1 variants is one
of the major factors responsible for therapeutic failure in persons living with HIV (PLWH) as
it jeopardizes the efforts to ...
Developing an Automated Panel Design Tool for SNP-Based Targeted Amplicon Sequencing of Schistosoma mansoni Populations
(Makerere University, 2022-08-26)
Genomic surveillance of Schistosomiasis across endemic regions could provide insights into the efficacy of current control strategies and allow the impact of selection on the parasite genome to be monitored, providing early ...
Effect of aqueous extracts of Moringa oleifera leaves on serum C-peptide levels in alloxan mono-hydrate induced diabetic wistar albino rats
(Makerere University, 2022-01-28)
ABSTRACT
Background: Moringa oleifera is rich in phytochemicals, and in Uganda, its leaves, roots and seeds are widely consumed for self-medication by patients affected by diabetes mellitus, hypertension, HIV/AIDS and ...
Predicting major depressive disorder among adults Living with HIV In Uganda: An Artificial Intelligence Approach
(Makerere University, 2022-08-01)
Background
Major depressive disorder is a leading cause of disability worldwide and a major contributor
to the overall global burden of disease. The biggest percentage of the MDD burden pertains to
low- and middle-income ...
Using Gene and miRNA expression profiles in Breast cancer risk prediction : a machine learning-based approach
(Makerere University, 2022)
Breast cancer (BC) incidence is commonly accompanied by poor treatment outcomes due to late diagnosis. BC risk prediction is important for timely diagnosis but it’s clinical utility is limited by high risk bias. Genetic ...