College of Health Sciences (CHS): Recent submissions
Now showing items 101-120 of 3383
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Correlation between co-therapy of efavirenz-based ART and pregnancy among HIV-positive women on hormonal contraceptive implants at TASO Tororo-Uganda: A retrospective review
(2018)Background: We examined the association between EFV and non-EFV based ART regimens and pregnancy outcomes among women who were on HCI in a peri-urban HIV clinic in Tororo, Uganda. Methods: We reviewed and extracted routinely ... -
Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
(BioMed Central, 2018)HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although ... -
Prevalence of lipodystrophy and metabolic abnormalities in HIV-infected African children after 3 years on first-line antiretroviral therapy
(Lippincott, 2015)Background: Most pediatric lipodystrophy data come from high-income/ middle-income countries, but most HIV-infected children live in sub-Saharan Africa, where lipodystrophy studies have predominantly investigated stavudine-based ... -
Impaired renal function and associated risk factors in newly diagnosed HIV-infected adults in Gulu Hospital, Northern Uganda
(BioMed Central, 2015)Background: Screening for renal diseases should be performed at the time of diagnosis of human immunodeficiency virus (HIV) infection. Despite the high prevalence of HIV/AIDS in Northern Uganda, little is known about the ... -
Feasibility of conducting a pilot randomized control trial of a psycho-education intervention in patients with a first episode psychosis in Uganda—A study protocol
(PLoS ONE, 2022)Background. Psychotic disorders contribute to significant morbidity and mortality partly due to the chronicity of the illness and high relapse rates. Delivering psycho-education messages about disease etiology, their signs ... -
Gastrointestinal cryptococcoma – Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?
(Elsevier, 2015)The introduction of antiretroviral therapy (ART) may lead to unusual paradoxical and unmasking presentations of opportunistic infections. Intra-abdominal cryptococcosis is a rare manifestation of Cryptococcus. We present ... -
Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda
(BioMed Central Infectious Diseases, 2015)Background: Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be ... -
Evaluation of four chemotherapy regimens for treatment of advanced AIDS-associated Kaposi Sarcoma in Kenya: A cost-effectiveness analysis
(Elsevier, 2022)Background The most effective treatment for advanced AIDS-associated Kaposi sarcoma is paclitaxel or pegylated liposomal doxorubicin (PLD); neither is routinely used in sub-Saharan Africa due to limited availability and ... -
Midwives’ perspectives about using individualized care plans in the provision of immediate postpartum care in Uganda; an exploratory qualitative study
(BMC, 2023)Introduction Individualized care planning has been slowly integrated into practice in Uganda with minimal documentation of how the concept is applied in providing care. This study explored the perceptions of midwives about ... -
Telling the story of intersectional stigma in HIV-associated Kaposi’s sarcoma in Western Kenya: A convergent mixed-methods approach
(Wiley Online Library, 2022)Introduction: The experience of stigma can be multifaceted for people with HIV and cancer. Kaposi’s sarcoma (KS), one of the most common HIV-associated cancers in sub-Saharan Africa, often presents with visible skin lesions ... -
Barriers and facilitators to chemotherapy initiation and adherence for patients with HIV-associated Kaposi’s sarcoma in Kenya: A qualitative study
(BMC, 2022)Background: Kaposi sarcoma is one of the most prevalent HIV‑associated malignancies in sub‑Saharan Africa and is often diagnosed at advanced stage of disease. Only 50% of KS patients who qualify for chemotherapy receive ... -
Viral load status before switching to dolutegravir-containing antiretroviral therapy and associations with Human Immunodeficiency Virus treatment outcomes in Sub-Saharan Africa
(Oxford University Press, 2021)Background. Dolutegravir is being rolled out globally as part of preferred antiretroviral therapy (ART) regimens, including among treatment-experienced patients. The role of viral load (VL) testing before switching patients ... -
Understanding diagnostic delays for kaposi sarcoma in Kenya: A qualitative study
(2022)Background: Although HIV-associated Kaposi sarcoma (KS) is frequently diagnosed at an advanced stage in sub-Saharan Africa, reasons for diagnostic delays have not been well described. Methods: We enrolled patients >18 years ... -
Postpartum care in Uganda: facility readiness, midwives perspectives, individualized care planning and patient outcomes
(Makerere university, 2025)Background: Globally, a woman dies every two minutes due to pregnancy or childbirth. Two-thirds of maternal deaths occur in the postpartum period and in Sub-Saharan Africa due to preventable causes such as sepsis, postpartum ... -
Marginal men, respectable masculinity and access to HIV services through intimate relationships with female sex workers in Kampala, Uganda
(Elsevier, 2022)Masculinity influences men’s sexual risk-taking behaviour and affects uptake of HIV services. We draw on data from a year-long (2019) ethnographic study focusing on men in relationships with female sex workers (FSW) in ... -
Factors associated with Rabies vaccination uptake by Dog owners in Butaleja Town Council, Butaleja District
(Makerere University, 2025)Introduction: Rabies, a deadly zoonotic disease, remains a global threat, especially in Africa and Asia. Despite being preventable through dog vaccination, low uptake persists, posing public health and economic risks. ... -
Assessing the knowledge and practices of health workers on the management of Rift Valley Fever in Kabale District, South Western Uganda
(Makerere University, 2024)Background: Rift Valley fever (RVF) is a zoonotic viral hemorrhagic disease caused by the Rift Valley Fever virus (RVFV), predominantly affecting Africa and the Arabian Peninsula. Majority of the outbreaks in Uganda are ... -
Assessing the effectiveness of contact tracing for multi drug resistant tuberculosis in Uganda
(Makerere University, 2024)Introduction: Multidrug-resistant tuberculosis (MDR-TB) poses a big threat in to the management of Tuberculosis (TB) disease in many countries including Uganda. MDR - TB can be transmitted from one person to another through ... -
Safety, effectiveness and acceptability of misoprostol for treatment of incomplete mid trimester abortion in Uganda
(Makerere University, 2023-07)Eight percent of the maternal deaths in Uganda are abortion-related and yet women still have limited access to quality postabortion care. Task sharing is a proposed strategy to increase access to safe postabortion care and ... -
Mobility patterns of index tuberculosis cases and tuberculosis transmission niches in Kampala
(Makerere University, 2024)Introduction: TB control relies on minimizing transmission from infectious to susceptible individuals. In Uganda, Kampala faces significant TB challenges, with index cases playing a key role in disease spread. Understanding ...