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Now showing items 11-20 of 46
Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisinin combination therapy: complexity of infection during short-term culture and characterization of in vitro sensitivity in Kampala Uganda
(Makerere University, 2010)
Background: Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant ...
Chlorproguanil-dapsone for treating uncomplicated malaria (Review)
(JohnWiley & Sons, 2010)
Background In Africa, malaria is often resistant to chloroquine and sulfadoxine-pyrimethamine. Chlorproguanil-dapsone is a potential alternative. Objectives To compare chlorproguanil-dapsone with other antimalarial drugs ...
Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
(BioMed Central, 2012-04-27)
Background: Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to assess ...
Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults
(Oxford University Press, 2012)
Objectives: Co-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug–drug interactions between artemether/lumefantrine and efavirenz ...
Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trial
(BioMed Central, 2011)
Background: Infection with severe malaria in African children is associated with not only a high mortality but also a high risk of cognitive deficits. There is evidence that interventions done a few years after the illness ...
Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviour
(BioMed Central, 2011-11-03)
Background
Malaria is a leading cause of ill health and neuro-disability in children in sub-Saharan Africa.
Impaired cognition is a common outcome of malaria with neurological involvement. There is
also a possibility ...
Daily co-trimoxazole prophylaxis in severely immunosuppressed HIV-infected adults in Africa started on combination antiretroviral therapy: an observational analysis of the DART cohort
(Elsevier, 2010-03-29)
Background: Co-trimoxazole prophylaxis can reduce mortality from untreated HIV infection in Africa; whether benefits occur alongside combination antiretroviral therapy (ART) is unclear. We estimated the effect of prophylaxis ...
Hemoglobin status and its association with age in children under five years in the Central Region of Uganda.
(Makerere University, 2012-04)
Background: The hemoglobin concentration is widely used as an aid in assessment of state of health. A sound factual basis is therefore necessary for establishing the trend of hemoglobin values its relation to age. WHO ...
Comparison of malaria morbidity before and after indoor residual spraying in Kanungu District, Uganda
(Makerere University, 2011-11)
Background: Malaria remains one of the most serious global health problems and a leading cause of morbidity and mortality. Malaria causes more illness and death than any other single disease in Uganda. In Kanungu district, ...
Malaria treatment practice and clinical presentation of adult patients with antimalarial prescriptions in Mulago hospital assessment centre.
(Makerere University, 2013)
Back ground: Malaria is a major cause of morbidity and mortality worldwide. It is endemic in over 95% of Uganda and accounts for 25-40% of all outpatient attendances. The World Health Organisation recommends parasitological ...