Browsing College of Health Sciences (CHS) by Author "Kamya, Moses R."
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Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda
Yeka, Adoke; Kamya, Moses R.; Dorsey, Grant; Talisuna, Ambrose; Lugemwa, Myers; Rwakimari, John Bosco; Staedke, Sarah G.; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Bukirwa, Hasifa (Public Library of Science, 2008-06)Background: Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ... -
An assessment of implementation science research capacity in Uganda
Semeere, Aggrey S.; Semitala, Fred C.; Lunkuse, Olivia; Katahoire, Anne; Sewankambo, Nelson K.; Kamya, Moses R. (BioMed Central, 2021)Background: In Uganda and other resource-poor countries, relevant research findings face a tortuous path to translation into policy and routine practice. Implementation science (ImSc) research could facilitate faster ... -
Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda
Wanyama, Jane; Castelnuovo, Barbara; Wandera, Bonnie; Mwebaze, Patricia; Kambugu, Andrew; Bangsberg, David R.; Kamya, Moses R. (Lippincott Williams & Wilkins., 2007)Although recent data suggest high levels of adherence to expanding antiretroviral therapy (ART) programmes in resource-limited settings, the culture- specific barriers to adherence are poorly understood. In a prospective ... -
Burden of tuberculosis in Kampala, Uganda
Guwatudde, David; Zalwango, Sarah; Kamya, Moses R.; Debanne, Sara M.; Diaz, Mireya I.; Okwera, Alphonse; Mugerwa, Roy D.; King, Charles; Whalen, Christopher C. (World Health Organization (WHO), 2008)Objective: To determine the prevalence and incidence of tuberculosis in one of Uganda’s poor peri-urban areas. Methods: Multi-stage sampling was used to select a sample of households whose members were evaluated for presence ... -
Changing malaria fever test positivity among paediatric admissions to Tororo district hospital, Uganda 2012–2019
Mpimbaza, Arthur; Sserwanga, Asadu; Rutazaana, Damian; Kapisi, James; Walemwa, Richard; Suiyanka, Laurissa; Kyalo, David; Kamya, Moses R.; Opigo, Jimmy; Snow, Robert W. (BMC, 2020)Background: The World Health Organization (WHO) promotes long-lasting insecticidal nets (LLIN) and indoor residual house-spraying (IRS) for malaria control in endemic countries. However, long-term impact data of vector ... -
Doctoral training in Uganda: evaluation of mentoring best practices at Makerere University College of Health Sciences
Nakanjako, Damalie; Katamba, Achilles; Kaye, Dan K.; Okello, Elialilia; Kamya, Moses R.; Sewankambo, Nelson; Mayanja-Kizza, Harriet (BMC Medical Education, 2014)Background: Good mentoring is a key variable for determining success in completing a doctoral program. We identified prevailing mentoring practices among doctoral students and their mentors, identified common challenges ... -
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
Kamya, Moses R.; Gasasira, Anne F.; Yeka, Adoke; Bakyaita, Nathan; Nsobya, Samuel L.; Damon, Francis; Rosenthal, Philip J.; Dorsey, Grant; Havlir, Diane (University of Chicago Press, 2005-11-18)Background. Human immunodeficiency virus (HIV) infection may increase the burden of malaria by increasing susceptibility to infection or by decreasing the response to antimalarial treatment. We investigated the seroprevalence ... -
Evaluation of Dynabeads and Cytospheres Compared With Flow Cytometry to Enumerate CD41 T Cells in HIV-Infected Ugandans on Antiretroviral Therapy
Lutwama, Fred; Serwadda, Ronnie; Mayanja-Kizza, Harriet; Shihab, Hasan M.; Ronald, Allan; Kamya, Moses R.; Thomas, David; Johnson, Elizabeth; Quinn, Thomas C.; Moore, Richard D.; Spacek, Lisa A. (Lippincott Williams & Wilkins., 2008-07-01)Background: Laboratory-based monitoring of antiretroviral therapy is essential but adds a significant cost to HIV care. The World Health Organization 2006 guidelines support the use of CD4 lymphocyte count (CD4) to define ... -
High CD56++CD16- natural killer (NK) cells among suboptimal immune responders after four years of suppressive antiretroviral therapy in an African adult HIV treatment cohort
Bayigga, Lois; Nabatanzi, Rose; Naluyima Sekiziyivu, Prossy; Mayanja-Kizza, Harriet; Kamya, Moses R.; Kambugu, Andrew; Olobo, Joseph; Kiragga, Agnes; Kirimunda, Sam; Joloba, Moses; Nakanjako, Damalie (BMC Immunology, 2014)Background: Up to 40% of HIV-infected individuals receiving Highly Active Antiretroviral Therapy (HAART) have poor CD4+ T-cell recovery. The role of natural killer (NK) cells in immune recovery during HAART is not well ... -
HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children
Boivin, Michael J.; Bangirana, Paul; Kamya, Moses R.; Achan, Jane; Akello, Carolyne; Wong, Joseph K.; Boal, Hannah E.; Ruel, Theodore D.; Havlir, Diane V.; Charlebois, Edwin; Eller, Leigh A.; Cao, Huyen (Lippincott Williams & Wilkins, 2010)Background: HIV-subtype D is associated with more rapid disease progression and higher rates of dementia in Ugandan adults compared with HIV-subtype A. There are no data comparing neuropsychological function by HIV subtype ... -
Impaired T-cell proliferation among HAARTtreated adults with suboptimal CD4 recovery in an African cohort
Nakanjako, Damalie; Ssewanyana, Isaac; Nabatanzi, Rose; Kiragga, Agnes; Kamya, Moses R.; Cao, Huyen; Mayanja-Kizza, Harriet (BMC Immunology, 2013)Background: Most HIV-infected subjects exhibit a progressive rise in CD4 T-cell counts after initiation of highly active antiretroviral therapy (HAART). However, a subset of individuals exhibit very poor CD4 T-cell recovery ... -
K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors
Ocan, Moses; Akena, Dickens; Nsobya, Sam; Kamya, Moses R.; Ssenono, Richard; Kinengyere, Alison Annet; Obuku, Ekwaro (Malaria Journal, 2019)Background: Efficacy of artemisinin (ART) agents, a critical element of current malaria control efforts is threatened by emergence and spread of resistance. Mutations in pfkelch13 gene associated with ART-resistance evolved ... -
Malaria diagnosed in an urban setting strongly associated with recent overnight travel: A case–control study from Kampala, Uganda
Arinaitwe, Emmanuel; Mpimbaza, Arthur; Nankabirwa, Joaniter I.; Kamya, Victor; Asiimwe, Alan; Kuule, Julius K.; Kamya, Moses R.; Drakeley, Chris; Dorsey, Grant; Rosenthal, Philip J.; Staedke, Sarah G. (2020)Malaria is frequently diagnosed in urban Kampala, despite low transmission intensity. To evaluate the association between recent travel out of Kampala and malaria, we conducted a matched case–control study. Cases were ... -
Measuring the outcomes of a comprehensive HIV care course: pilot test at the Infectious Diseases Institute, Kampala, Uganda
Weaver, Marcia R; Nakitto, Cecilia; Schneider, Gisela; Kamya, Moses R.; Kambugu, Andrew; Lukwago, Robinah; Ronald, Allan; McAdam, Keith; Sande, Merle A. (Lippincott Williams & Wilkins, 2006)Objective: To evaluate the effects of the Infectious Diseases Institute’s 4-week course for African doctors on comprehensive management of HIV including antiretroviral therapy on four outcomes: (1) clinical skills, (2) ... -
A need to accelerate health research productivity in an African University: the case of Makerere University College of Health Sciences.
Nakanjako, Damalie; Akena, Dickens; Kaye, Dan K.; Tumwine, James; Okello, Elialilia; Kamya, Moses R.; Nakimuli, Annettee; Kambugu, Andrew; McCullough, Hazel; Mayanja-Kizza, Harriet; Sewankambo, Nelson K. (Health Research Policy and Systems, 2017)Background: In the last decade, Makerere University College of Health Sciences (MakCHS) has taken strides in research and training to improve healthcare through collaborative training and research programs. However, ... -
Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
Kambugu, Andrew; Meya, David B.; Rhein, Joshua; O’Brien, Meagan; Janoff, Edward N.; Ronald, Allan R.; Kamya, Moses R.; Mayanja-Kizza, Harriet; Sande, Merle A.; Bohjanen, Paul R.; Boulware, David R. (CID, 2008)Background. Cryptococcal meningitis (CM) is the proximate cause of death in 20%–30% of persons with acquired immunodeficiency syndrome in Africa. Methods. Two prospective, observational cohorts enrolled human immunodeficiency ... -
Practical implications of a relationship between health management information system and community cohort–based malaria incidence rates
Kigozi, Simon P.; Giorgi, Emanuele; Mpimbaza, Arthur; Kigozi, Ruth N.; Bousema, Teun; Arinaitwe, Emmanuel; Nankabirwa, Joaniter I.; Sebuguzi, Catherine M.; Kamya, Moses R.; Staedke, Sarah G.; Dorsey, Grant; Pullan, Rachel L. (2020)Global malaria burden is reducing with effective control interventions, and surveillance is vital to maintain progress. Health management information system (HMIS) data provide a powerful surveillance tool; however, its ... -
Prevalence and factors associated with cryptococcal antigenemia among severely immunosuppressed HIV-infected adults in Uganda: a cross-sectional study
Oyella, Jacinta; Meya, David; Bajunirwe, Francis; Kamya, Moses R. (Journal of the International AIDS Society, 2012-03-14)Background: Cryptococcal infection is a common opportunistic infection among severely immunosuppressed HIV patients and is associated with high mortality. Positive cryptococcal antigenemia is an independent predictor of ... -
Rapid shifts in the age‑specific burden of malaria following successful control interventions in four regions of Uganda
Kigozi, Simon P.; Kigozi, Ruth N.; Epstein, Adrienne; Mpimbaza, Arthur; Sserwanga, Asadu; Yeka, Adoke; Nankabirwa, Joaniter I.; Halliday, Katherine; Pullan, Rachel L.; Rutazaana, Damian; Sebuguzi, Catherine M.; Opigo, Jimmy; Kamya, Moses R.; Staedke, Sarah G.; Dorsey, Grant; Greenhouse, Bryan; Rodriguez‑Barraquer, Isabel (BMC, 2020)Background: Malaria control using long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) has been associated with reduced transmission throughout Africa. However, the impact of transmission ... -
Strategies to optimize HIV treatment outcomes in resource-limited settings
Nakanjako, Damalie; Colebunders, Robert; Coutinho, Alex G.; Kamya, Moses R. (Permanyer Publications, 2009)Although the availability of antiretroviral therapy has increased rapidly to reach over three million people in low- and middle-income countries, coverage remains low as only 31% of people in need were receiving antiretroviral ...