Infectious Diseases Institute (IDI) Collections: Recent submissions
Now showing items 21-40 of 159
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Characteristics and outcomes of admitted patients infected with SARS-CoV-2 in Uganda
(BMJ, 2020)Rationale: Detailed data on the characteristics and outcomes of patients with COVID-19 in sub-Saharan Africa are limited. Objective: We determined the clinical characteristics and treatment outcomes of patients diagnosed ... -
Metabolic syndrome and 10-year cardiovascular risk among HIV-positive and HIV-negative adults: A cross-sectional study
(Wolters Kluwer, 2020)To determine the prevalence and correlates of metabolic syndrome (MetS) and compare 10-year cardiovascular disease (CVD) risk among Kenyan adults with and without HIV infection.We conducted a cross-sectional study among ... -
Intimate partner violence and self-reported pre-exposure prophylaxis interruptions among HIV-negative partners in HIV serodiscordant couples in Kenya and Uganda
(Lippincott, 2018)Background: Oral pre-exposure prophylaxis (PrEP) is effective for HIV prevention, and PrEP delivery studies are investigating ways to deliver PrEP with high adherence. However, in many settings with high HIV burden, intimate ... -
Tuberculosis preventive therapy (TPT) to prevent tuberculosis co-infection among adults with HIV-associated cryptococcal meningitis: A clinician's perspective
(Elsevier, 2020)As part of the END TB strategy, the World Health organization (WHO) recommends provision of tuberculosis preventive therapy (TPT) to all people at high risk of developing active TB disease. Patients with HIV-associated ... -
Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda
(BMC, 2020)Background: Management of co-infections including cryptococcal meningitis, tuberculosis and other opportunistic infections in persons living with HIV can lead to complex polypharmacotherapy and increased susceptibility to ... -
High viral suppression and low attrition in healthy HIV-infected patients initiated on ART with CD4 above 500 cells/μL in a program setting in Uganda
(African Health Sciences, 2020)Background: The World Health Organization recommends antiretroviral therapy (ART) for all HIV-infected patients at all CD4 counts. However, there are concerns that asymptomatic patients may have poorer viral suppression ... -
Research priorities to inform “Treat All” policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA)
(Wiley Online Library, 2019)Introduction “Treat All” – the treatment of all people with HIV, irrespective of disease stage or CD4 cell count – represents a paradigm shift in HIV care that has the potential to end AIDS as a public health threat. With ... -
Pharmacokinetic and pharmacodynamic considerations of rifamycin antibiotics for the treatment of tuberculosis
(Taylor and Francis, 2019)Tuberculosis (TB) treatment was revolutionized in 1965 with the discovery of rifamycins by Sensi et al. [1]. With the introduction of rifamycins, treatment duration drastically decreased from 18 to 6 months [2]. Rifamycins, ... -
Prevalence, correlates, and predictive value of high-risk human papillomavirus mRNA detection in a community-based cervical cancer screening program in Western Uganda
(BMC, 2019)Background: New strategies are needed to combat the high incidence of cervical cancer in resource-limited settings such as sub-Saharan Africa. Screening for high-risk human papillomavirus (hrHPV) DNA is sensitive for ... -
Longer-term effectiveness of protease-inhibitor-based second line antiretroviral therapy in four large sub-Saharan African clinics
(Elsevier, 2019)Objectives: Data on the longer-term effectiveness of second line combination antiretroviral therapy (ART) in sub-Saharan Africa (SSA) are lacking. We sought to assess the probability and determinants of 2nd line ART ... -
Depressive and anxiety symptoms predict sustained quality of life deficits in HIV-positive Ugandan adults despite antiretroviral therapy
(Lippincott, 2016)The impact of psychosocial status at onset of antiretroviral therapy on changes in quality of life (QOL) and subjectively rated health (SRH) among adults on ART in resource-limited settings is poorly understood. Therefore, ... -
Improving the Sensitivity of the Xpert MTB/RIF Assay on sputum pellets by decreasing the amount of added sample reagent: a laboratory and clinical evaluation
(American Society for Microbiology, 2015)The Xpert MTB/RIF(Xpert) assay permits rapid near-patient detection of Mycobacterium tuberculosis in sputum; however, the test sensitivity remains suboptimal in paucibacillary specimens that are negative for acid-fast ... -
Treatment of HIV/AIDS. Do the dilemmas only increase?
(American Medical Association, 2004)Physicians and other health care professionals who treat patients with human immunodeficiency virus (HIV)/AIDS are confronted daily with complex challenges. Fortunately, several articles in this theme issue of JAMA on ... -
Hepatitis B and C seroprevalence among health care workers in a tertiary hospital in Rwanda
(Oxford University Press, 2015)Background: Hepatitis B (HBV) and hepatitis C (HCV) are significant global public health challenges with health care workers (HCWs) at especially high risk of exposure in resource-poor settings. We aimed to measure HBV and ... -
Estimation of mortality among HIV-infected people on antiretroviral therapy treatment in East Africa: a sampling based approach in an observational, multisite, cohort study
(Elsevier, 2015)Background—Mortality after initiation of antiretroviral treatment (ART) among HIV-infected patients in resource limited settings is a critical measure of the effectiveness and comparative effectiveness of the global public ... -
Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting
(Lippincott Williams & Wilkins, 2004)Background: There are no validated measures of adherence to HIV antiretroviral therapy in resource-poor settings. Such measures are essential to understand the unique barriers to adherence as access to HIV antiretroviral ... -
Growing older with HIV in the treat-all era
(Wiley, 2022)One of the most impactful global public health interventions of modern times has been antiretroviral therapy (ART). This has led to reduced HIV transmission; reduced morbidity from opportunistic infections; and dramatically ... -
Implementing screening for hypertension in archetypal HIV primary care: a mixed-methods assessment
(BMC, 2022)Background: High prevalence of HIV and hypertension in sub-Saharan Africa puts adults living with HIV (ALWH) at high risk of end-organ complications. Both World Health Organization (WHO) and national guidelines recommend ... -
Increased prevalence of pregnancy and comparative risk of program attrition among individuals starting HIV treatment in East Africa
(PLoS ONE, 2018)Background The World Health Organization now recommends initiating all pregnant women on life-long antiretroviral therapy (ART), yet there is limited information about the characteristics and program outcomes of pregnant ... -
Cryptococcal disease in the era of “test and treat”: Is there cause for concern?
(Oxford University Press, 2017)Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution ...