Search
Now showing items 1-5 of 5
Whole exome sequencing uncovers genetic predisposition to pediatric HIV disease progression and hyperhemolysis syndrome
(Makerere University, 2022-07)
Background: Populations of African ancestry hold a disproportionate burden of infectious and non-infectious diseases. Genetic variants, with population allele frequencies ranging from rare to common variants, are believed ...
Monitoring antibacterial use in children under five years in rural communities of Northern Uganda
(Makerere University, 2022)
Background: Acute respiratory tract infections (ARIs) and diarrhea are leading causes of childhood morbidity and mortality in low- and middle-income countries (LMICs), the burden is high among children under five years of ...
Pharmacokinetic/pharmacodynamic Modeling to optimize efavirenz dosing in HIV/AIDs infected children from Sub-Saharan Africa.
(Makerere University, 2022-12)
Aim:Using a model‐based approach, the efavirenz steady‐state pharmacokinetics in Sub-Saharan African children is characterized, quantifying demographic and genotypic effects on the drug's disposition. Simulations are also ...
Effects of Helminth Infections on Type-2 Immune Responses in children with asthma
(Makerere University, 2023-11-14)
Background: Both asthma and helminths demonstrate a predominant type-2 immune response. Additionally, helminths have been demonstrated to have immuno-modulatory roles in allergic conditions such as asthma. Therefore, the ...
Antimicrobial stewardship practices and quality of antibacterial use in children under five and women in labour with obstetric risk factors in selected health facilities in Uganda
(Makerere University, 2024)
Introduction
Bacterial infections are a leading cause of morbidity and mortality in Ugandan hospitalised children under the age of five. Disparities exist in using antibacterial agents to treat bacterial infections at ...