Browsing by Subject "Quinine"
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Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans
(Lippincott Wilkins & Williams, 2010)Abstract: Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This ... -
Quinine-related adverse drug reactions among malaria patients in Lira Regional Referral Hospital
(Makerere University, 2014-10)Introduction: Quinine is the most effective second-line antimalarial drug but its clinical use is usually limited due to the numerous side effects. Sex difference in quinine disposition is a possible key determinant of ...